2014·Genes & development
Human high-altitude adaptation: forward genetics meets the HIF pathway
Bigham AW, Lee FS.
Read at the journaldoi:10.1101/gad.250167.114
Abstract
Humans have adapted to the chronic hypoxia of high altitude in several locations, and recent genome-wide studies have indicated a genetic basis. In some populations, genetic signatures have been identified in the hypoxia-inducible factor (HIF) pathway, which orchestrates the transcriptional response to hypoxia. This review by Bigham and Lee discusses these findings on human adaptation to high altitude.
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