Evolutionary genomic dynamics of Peruvians before, during, and after the Inca Empire
Harris DN, Song W, Shetty AC, Levano KS, Cáceres O, Padilla C, Borda V, Tarazona D, Tarazona D, Trujillo O, Sanchez C, Kessler MD, Galarza M, Capristano S, Montejo H, Flores-Villanueva PO, Tarazona-Santos E, O'Connor TD, Guio H.
Abstract
Through the Peruvian Genome Project we generate and analyze the genomes of 280 individuals where the majority have >90% Native American ancestry and explore questions at the interface of evolutionary genetics, history, anthropology, and medicine. This is the most extensive sampling of high-coverage Native American and mestizo whole genomes to date. We estimate an initial peopling of Peru was rapid and began by 12,000 y ago. In addition, the mestizo populations exhibit admixture between Native American groups prior to their Spanish admixture and was likely influenced by the Inca Empire and Spanish conquest. Our results address important Native American population history questions and establish a dataset beneficial to address the underrepresentation of Native American ancestry in sequencing studies. Keywords: Native American demography, identity by descent, population history, gene flow, fine-scale structure
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