2021·Proceedings of the National Academy of Sciences of the United States of America
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
Zeberg H, Pääbo S.
Read at the journaldoi:10.1073/pnas.2026309118
Abstract
We show that a haplotype on chromosome 12, which is associated with a ∼22% reduction in relative risk of becoming severely ill with COVID-19 when infected by SARS-CoV-2, is inherited from Neandertals. This haplotype is present at substantial frequencies in all regions of the world outside Africa. The genomic region where this haplotype occurs encodes proteins that are important during infections with RNA viruses.
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