The genetic history of the Southern Arc: a bridge between West Asia and Europe

Abstract

Author Manuscript By sequencing 727 ancient individuals from the Southern Arc (Anatolia and neighbors in Southeastern Europe and West Asia) over 10,000 years, we contextualize its Chalcolithic and Bronze Ages (~5000-1000BCE), when extensive gene flow entangled it with the Eurasian steppe. Two streams of migration transmitted Caucasus and Anatolian/Levantine ancestry northward, and the Yamnaya pastoralists, formed on the steppe, then spread southwards: into the Balkans, and across the Caucasus into Armenia, where they left numerous patrilineal descendants. Anatolia was transformed by intra-West Asian gene flow, with negligible impact of the later Yamnaya migrations. This contrasts with all other regions where Indo-European languages were spoken, suggesting that the homeland of the Indo-Anatolian language family was in West Asia, with only secondary dispersals of non-Anatolian Indo-Europeans from the steppe. One-Sentence Summary: Author Manuscript Web of migrations between Anatolia, its neighbors, and the Steppe suggests a West Asian origin of Indo-Anatolian languages. Print page summary * Author Manuscript Corresponding authors. Iosif Lazaridis (lazaridis@genetics.med.harvard.edu), Songül Alpaslan-Roodenberg (msglalpaslan@gmail.com), Ron Pinhasi (ron.pinhasi@univie.ac.at), David Reich (reich@genetics.med.harvard.edu). †Co-lead authors